![]() Among available opioids, buprenorphine has been suggested to be advantageous for a series of clinical reasons, partly explained by its unique pharmacological characteristics. ![]() The main problems related to chronic opioid use are respiratory depression, severe constipation, tolerance, and the risk of abuse and dependence. Each opioid may have a different kinetic and dynamic profile, showing varying clinical utility or risks. Due to its very high distribution in the central and peripheral nervous systems (CNS and PNS), the opioid system plays a pivotal role in modulating pain and other physiological functions and pharmacological responses, including undesired side effects. Indeed, opioids are considered to be second- or third-choice drugs, after anticonvulsant and N-methyl-D-aspartate (NMDA) antagonists. Although opioids represent the major analgesics available for the treatment of moderate and severe pain, they do not provide effective analgesia in every type of neuropathic pain. The molecular and cellular mechanisms highlighting neuropathic pain have not yet been clarified. In this paper, we attempt to conceptualize the potential undiscovered dynamic profile of buprenorphine.Ĭhronic pain, including neuropathic pain, strongly affects the quality of life of patients and it remains still poorly pharmacologically managed. Pharmacokinetics optimization strategies, and additional potentialities, are still to be explored. However, questions on the dynamic profile remain to be answered. ![]() Some properties are partly explained by its unique pharmacological characteristics. Among available opioids compounds, buprenorphine has been suggested advantageous for a series of clinical reasons, including the effectiveness in neuropathic pain. In addition, opioids possess addictive properties that are associated with misuse and drug abuse. Moreover, these drugs show several side effects that limit their use. It is well known that opioids are the most powerful analgesic drugs, but they represent the second or third line in neuropathic pain, that remain difficult to manage. Chronic pain, including neuropathic pain, represents an untreated disease with important repercussions on the quality of life and huge costs on the national health system.
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